Short course on Engineering Microbubbles for Biomedical Applications
Microbubbles (MBs) are micron-sized, gaseous colloidal particles of 0.1-10 μm diameter in size, encapsulated in a stabilizing shell. The
microbubbles are used for contrast-enhanced ultrasound (CEUS) imaging, drug and gene delivery, including across the blood-brain barrier
(BBB), to dissolve clots and thrombus, and to oxygenate hypoxic tissue. This course will mainly deal with design and engineering of microbubbles for biomedical applications, such as ultrasonic imaging and targeted drug delivery. Methods of microbubble synthesis, techniques for microbubble characterization, and issues related to microbubble stability and biocompatibility will be discussed. A few specific examples related to targeted drug delivery using microbubbles, such as targeting tumors and opening the BBB will also be discussed. In addition to lectures, practical sessions will be held for demonstrations of microbubble synthesis and characterization.
8-12 January 2018
- Expose participants to the fundamentals of microbubble engineering for biomedical applications.
- Enhance understanding of the participants about the thermodynamics and kinetic processes involved in design and production of stable microbubble suspensions.
- To increase the awareness about the usefulness of microbubbles in important biomedical applications, such as ultrasound imaging and targeted drug delivery.
Lecture 1 : 1.5 hrs (MAB)
Introduction: Structure, characteristics, properties and applications of microbubbles; role of ultrasound.
Lecture 2: 1.5 hrs (MAB)
Synthesis of Microbubbles: Various techniques; advantages and disadvantages of these techniques.
Practical 1: 2 hrs (MAB/SVD)
Synthesis of microbubbles using the sonication method.
Lecture 3 : 1.5 hrs (MAB)
Producing narrow-sized microbubble suspensions:
Techniques to produce a narrow size distribution.
Lecture 4: 1.5 hrs (MAB)
Microfluidic devices: type, design, advantages and disadvantages.
Tutorial 2: 2 hrs (MAB/SVD)
Characterization of microbubbles.
Lecture 5 : 1.5 hrs (MAB)
Stability of microbubble suspensions.
Lecture 6: 1.5 hrs (MAB)
Thermodynamics and kinetics of microbubble dissolution.
Tutorial 3: 2 hrs (MAB/SVD)
Demonstration of isolation of narrow-sized population
Lecture 7 : 1.5 hrs (MAB)
Engineering microbubbles for biomedical imaging
Lecture 8: 1.5 hrs (MAB)
Engineering microbubbles for targeted drug delivery
Tutorial 4: 2 hrs (MAB/SVD)
In-vitro dissolution studies
Lecture 9: 1.5 hrs (MAB)
Biocompatibility of microbubbles
Lecture 10: 1.5 hrs (MVB)
Nanodroplets: Thermodynamics and kinetics of phase-change agents and their applications
Tutorial 5: 2 hrs (MAB/SVD)
Synthesis of drug-loaded microbubbles and in-vitro drug release.
- Prof. Mark Borden is an Associate Professor of Mechanical Engineering, Fellow of Materials Science Engineering and Affiliate Member of Bioengineering at the University of Colorado Boulder. He received a BS from the University ofArizona and PhD from the University of California Davis, both in chemical engineering. Borden’s research interests are in the areas of interfacial phenomena and transport phenomena, with an emphasis on bubbles, emulsions and foams. He is a world-renowned expert in the field of microbubble engineering for biomedical applications. His lab has started two biotech companies. Borden’s honors include the NSF CAREER Award and NYSTAR James D. Watson Investigator Award and invitation to the National Academy of Engineering Frontiers of Engineering symposium. He has published more than 80 journal articles in prestigious international journals, 11 patents and has
contributed to more than 140 conference papers, presentations and posters.
- Prof. Sameer V. Dalvi is an Associate Professor of Chemical Engineering, at IIT Gandhinagar. He has done his masters and PhD from IIT Bombay, both in Chemical Engineering. Dr Dalvi’s research interests are in the areas of colloidal suspensions and drug formulations, with key focus on the formulation of microbubbles as thernostic agents. He is recipient of NASI – Young Scientist Platinum Jubilee Award for the year 2015 by National Academy of Sciences, India, Young Engineers Award for the year 2010 by
Institution of Engineers (India). He has published around 28 journal articles in international journals and has contributed to 26 conference papers, presentations and posters.
Student: INR 1,000/- Faculty: INR 2,000/-
Industry/ Government lab: INR 5,000/-
Participants from outside India: US $500/-
The Course Fees include only Registration and Lunch.
Accommodation is not included. However, accommodation can be made available upon request and on payment-basis, subject to availability.
Account Name: IIT Gandhinagar Project & Consultancy
Acc No: 1414132000011 MICR No.: 380015052
Bank | Branch: Canara Bank, IIT Gandhinagar, Palaj
IFSc Code: CNRB0005159 Branch Code: 005159
How to Apply:
All interested individuals should send their CVs to firstname.lastname@example.org before December 15, 2017. The shortlisted candidates will be intimated by December 19, 2017. All shortlisted candidates should register online as mentioned below.
Step 1. Register at GIAN website and obtain GIAN registration ID here
Step 2: Register online for this course at IITGN: here
The candidates who want to pay fees by DD, should deposit DD at IIT Gandhinagar on January 8, 2018.
For more information visit Website.